New polygenic risk score could save lives in heart failure

Researchers at the University of Copenhagen have developed a new polygenic risk score with an increased predictive power for the diagnosis and prognosis of heart failure. Their results have recently been published in the leading journal Nature.

Heart failure is an unfortunately often overlooked condition where the heart’s working blood supply is reduced due to a build-up of plaque in the arteries. This develops to a point where the left ventricle and the left ventricle muscle, respectively, are not able to pump efficiently enough, and this results in a heart failure. At the same time, the degenerated blood-flow of the chest and the right ventricle of the heart are affected.


Heart failure is a condition that affects approximately one in every four people over the age of 45 in Denmark. Almost twice as many people are affected in this challenge. Heart failure arises when the left ventricle collapses and the left chambers are unable to adequately receive oxygen, the other important parts of the heart. In this way, the heart muscles are not able to dilate to properly dilate (i. e. increase blood flow). [/quote]

The researchers used their new score to analyze all the genetic predispositions of the 5000 participants of the Danish Genome Registry and have processed it for the rest of the population.