Research identifies one newly found brain circuit that contributes to motor control

Researchers at The University of Texas Health Science Center at Houston (UTHealth) have identifiedone newly discovered brain circuit that contributes to motor control through a circuit known as RMT. The research was published on July 14, 2019 in the journal Science Advances. It theorizes that schizophrenia affects our ability to select sexual partners, and it contributes to difficulties navigating social situations.

“I am a neuroscientist and psychologist. I love to think about the brain. We want to study how the human mind works. This is what led me to look for RMT in the brain, ” said Dr. Nicholas B. Cordis, assistant professor of Molecular and Integrative Biology at McGovern Medical School at UTHealth.

Cordis and his research collaborator Dr. Christina Robb, both in the University of California’s Department of Psychology, and their team began with a mouse model genetically modified to turn off the RMT gene in the mouse brain, and began a series of experiments. Among other tests, they bred rats that lacked the RMT gene and then used an electrophysiological method to make them lose half their brain volume so that they no longer performed a simple RMT task. The activity in the corresponding brain regions, the RMT circuit, was then measured while an injured rat was connected to a prosthetic limb.