Vigorous exercise during PAD can prevent, manage some cognitive impairment, almost all neurodegenerative disorders

People who have a poor motor skills due to a neurological condition known as PAD or Parkinson’s disease have difficulty in motivating themselves, and this is known to be a factor in dementia disease progression. Now scientists at the Centro Nacional de Investigaciones Neurólogiques Ricardo Nacional de Investigaciones Cellarites (CNII) of the University of Barcelona (UB) have analysed a large retrospective study of about four hundred participants of the Cardiovascular, Obesity and Related Disorders Cohort (CAND) and compared results with that done by the SVU Neurogene Consortium (SVN), a consortium on cerebro-psychiatric disorders.

The CAMERA participants, aged between 40 and 73, are of three groups: Those who were sedentary, those who had a moderate to severe amount of exercise and those who participated in intense physical activity of high intensity.

The CWIII study is the largest study on PAD, and it was carried out by the University of Girona, the Cardiovascular, Obesity, and Related Disorders Cohort (CAND) of the University of Barcelona, the Sant Joan de Las Palmas Children’s Hospital, and the University of Bergamo (Spain).

Researchers therefore analysed previous data on 266 people of the CGI cohort. For this purpose, they have acquired data from the webpages of the five to six year follow-up of the trial participants published by the Italian Ministry of Education and Research (MIN-ROM), Mental Health, and of the Spanish National Pharmacy Commissioning Authority (APC-OFID) starting in 2014, followed by a formalellement to the CAMERA study, following which information went more into a longitudinal format.

The study showed that most of the participants achieved a marked reduction in the risk for or severity of the neurodegenerative disorder beginning at the age of 40 years and in 90% of the cases, this remained until the age of 68 years. Although some cases of severe PAD occurred in the elderly and at a higher severity than others, the CI was about half that of 064 individuals with no dementia. The new findings were published on the basis of this study.

Regarding memory, which was assessed at the 18-year agepoints, and coordination abilities, the participants had no dementia, but after the age of 60 years, about 2-6 years of memory impairment, or about half of the population continued to have problems with it.

“From a very simple statistical analysis of the results, we could see that no serious cognitive impairment, mulligant etatorialis (impulsivity), or cerebro-pharmacological impairment (cleancreatic responsiveness) were observed among these numbers of individuals in the genome-wide association study, ” explain the authors of the article published in the journal BRAIN. “So far it has been impossible to have a quantitative comparison between the repeated, multi-omic analyses conducted on more than 500 individuals of the CGI cohort that was done by the SVN. “